Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500956 | 0.76 | KCNH2 (0.66) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6500952 | 0.76 | KCNH2 (0.66) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6472419 | 0.71 | OPRL1 (0.66) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6472418 | 0.71 | OPRL1 (0.66) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6504432 | 0.62 | KCNH2 (0.67) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6506705 | 0.62 | KCNH2 (0.67) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6471905 | 0.60 | OPRL1 (0.55) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6501770 | 0.60 | OPRL1 (0.70) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6471908 | 0.60 | OPRL1 (0.55) | OPRL1OPRM1KCNH2 | |
| SCHEMBL6471078 | 0.59 | OPRL1 (1.00) | OPRL1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016913-A1 | TETRAHYDROISOQUINOLINE OR ISOCHROMAN COMPOUNDS AS ORL-1 RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN AND CNS DISORDERS | PFIZER JAPAN, INC. (JP) | 2005-02-24 | — | — | WO | disclosed |