Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485755 | 1.00 | PDE4B (0.56) | PDE4BPDE4DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6485752 | 1.00 | PDE4B (0.56) | PDE4BPDE4DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6477017 | 1.00 | PDE4B (0.56) | PDE4BPDE4DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6488481 | 0.99 | PDE4B (0.56) | PDE4BPDE4DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6488485 | 0.99 | PDE4B (0.56) | PDE4BPDE4DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6488324 | 0.93 | PDE4B (0.61) | PDE4BPDE4DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6488321 | 0.93 | PDE4B (0.61) | PDE4BPDE4DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6478462 | 0.85 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6478012 | 0.85 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6478458 | 0.85 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933296-B2 | Compounds effective as β2-adrenoreceptor agonists as well as PDE4-inhibitors | ALTANA PHARMA B.V. (NL) | 2005-08-23 | — | — | US | disclosed |
| EP-1296956-A1 | COMPOUNDS EFFECTIVE AS BETA-2-ADRENORECEPTOR AGONISTS AS WELL AS PDE4-INHIBITORS | ALTANA Pharma AG (DE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001094319-A1 | COMPOUNDS EFFECTIVE AS BETA-2-ADRENORECEPTOR AGONISTS AS WELL AS PDE4-INHIBITORS | ALTANA PHARMA AG (DE) | 2001-12-13 | — | — | WO | disclosed |