Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.61 |
| ▸ | FLT1 | P17948 | 16/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.61 |
| ▸ | FLT4 | P35916 | 7/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7736062 | 0.89 | KDR (0.69) | KDRFLT1FGFR1FLT4EPHB2 | |
| Hydrochloric Acid SCHEMBL6896039 | 0.85 | KDR (0.55) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL6517819 | 0.85 | KDR (0.54) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL6519244 | 0.85 | KDR (0.59) | KDRFLT1FGFR1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL6485313 | 0.83 | KDR (0.51) | KDRFLT1FGFR1FLT4EPHB2 | |
| Hydrochloric Acid SCHEMBL7460941 | 0.82 | KDR (0.52) | KDRFLT1FGFR1FLT4EPHB2 | |
| Hydrochloric Acid SCHEMBL6517812 | 0.82 | KDR (0.54) | KDRFLT1FGFR1FLT4EGFR | |
| SCHEMBL6487092 | 0.81 | KDR (0.51) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL7460558 | 0.81 | KDR (0.50) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL1886550 | 0.80 | KDR (0.49) | KDRFLT1FGFR1FLT4EPHB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897210-B2 | Quinazoline derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 2005-05-24 | — | — | US | disclosed |