Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303 | 0.81 | CYP2A6 (0.38) | LPAR1MEN1LMNAKMT2ALPAR3 | |
| SCHEMBL1445 | 0.79 | TSHR (0.44) | LPAR1FAAHLPAR3TP53SIGMAR1 | |
| SCHEMBL7223 | 0.78 | LPAR1 (0.41) | LPAR1CYP1A2FAAHLPAR3LPAR2 | |
| SCHEMBL4348 | 0.78 | IGF1R (0.43) | LPAR1LMNALPAR3KDM4EPOLB | |
| SCHEMBL6642 | 0.76 | LPAR1 (0.39) | LPAR1FAAHLPAR3LPAR2BRD4 | |
| SCHEMBL6477 | 0.75 | LPAR1 (0.42) | LPAR1LMNALPAR3 | |
| SCHEMBL7104 | 0.73 | LPAR1 (0.34) | LPAR1CYP1A2MEN1LMNAKMT2A | |
| SCHEMBL1166 | 0.73 | LPAR1 (0.47) | LPAR1LMNALPAR3LPAR2HDAC1 | |
| SCHEMBL11123 | 0.72 | LPAR1 (0.40) | LPAR1LPAR3LPAR2HDAC1HDAC8 | |
| SCHEMBL6761 | 0.70 | LPAR1 (0.38) | LPAR1MEN1KMT2ALPAR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |