Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | FLT1 | P17948 | 4/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.40 |
| ▸ | FLT4 | P35916 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499250 | 0.96 | HDAC6 (0.49) | TNFHDAC6PDGFRBSRCHDAC3 | |
| SCHEMBL5562061 | 0.85 | HDAC6 (0.55) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL2922474 | 0.84 | TNF (0.54) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL664005 | 0.83 | HDAC6 (0.55) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL4386072 | 0.83 | TNF (0.49) | TNFHDAC6SRCKDREGFR | |
| SCHEMBL4380672 | 0.83 | HDAC6 (0.49) | TNFHDAC6PDGFRBHDAC3HDAC4 | |
| SCHEMBL2947219 | 0.83 | EHMT2 (0.50) | TNFHDAC6KDREHMT2EHMT1 | |
| SCHEMBL4381827 | 0.82 | HDAC6 (0.51) | TNFHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL6789011 | 0.82 | TNF (0.48) | TNFHDAC6SRCKDREGFR | |
| SCHEMBL7210734 | 0.82 | HDAC6 (0.53) | TNFHDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939866-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2005-09-06 | — | — | US | disclosed |
| US-20040044015-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2004-03-04 | — | — | US | disclosed |
| EP-1326860-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030926-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044015-A1 | Quinazoline derivatives | NQO2, NRAS, TOP1 | TNF 1747/4885HDAC6 1075/4885PDGFRB 2921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.