Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.73 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.59 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | IGF1R | P08069 | 3/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6481339 | 0.87 | TEK (0.72) | TEKEPHB4FGFR3FGFR2KDR | |
| SCHEMBL14214552 | 0.87 | TEK (0.81) | TEKEPHB4FGFR3FGFR2KDR | |
| SCHEMBL6480986 | 0.83 | TEK (0.74) | TEKEPHB4FGFR3FGFR2KDR | |
| SCHEMBL2325736 | 0.83 | TEK (0.66) | TEKEPHB4FGFR3FGFR2KDR | |
| SCHEMBL6487760 | 0.82 | TEK (0.70) | TEKEPHB4FGFR3FGFR2KDR | |
| SCHEMBL14214551 | 0.81 | TEK (0.78) | TEKFGFR3FGFR2KDRAURKB | |
| SCHEMBL14214679 | 0.80 | PRKD3 (0.69) | TEKEPHB4FGFR3FGFR2KDR | |
| SCHEMBL14214736 | 0.80 | TEK (0.75) | TEKEPHB4FGFR3FGFR2KDR | |
| SCHEMBL6480089 | 0.80 | TEK (0.69) | TEKFGFR3FGFR2KDRAURKB | |
| SCHEMBL15977018 | 0.79 | EGFR (0.59) | TEKEPHB4FGFR3FGFR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6864255-B2 | Substituted triazinyl amide derivatives and methods of use | AMGEN INC. (US) | 2005-03-08 | — | — | US | disclosed |
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| US-20030087908-A1 | Substituted triazinyl amide derivatives and methods of use | AMGEN INC. | 2003-05-08 | — | — | US | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087908-A1 | Substituted triazinyl amide derivatives and methods of use | FLT4, FLT1, VEGFA | TEK 6/4885EPHB4 2420/4885FGFR3 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.