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Sugi Predict / Compounds / SCHEMBL6481665

SCHEMBL6481665

SCHEMBL6481665

O=C(O)Cc1ccc(OC/C=C(/c2ccc(-c3ccccc3)cc2)c2cnc(-c3ccccc3)s2)c(Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARD Q03181 7/20 0.61
▸ NPC1 O15118 4/20 0.45
▸ RAB9A P51151 4/20 0.45
▸ ALDH1A1 P00352 4/20 0.45
▸ CYP1A2 P05177 3/20 0.45
▸ SMN1; SMN2 Q16637 4/20 0.43
▸ NFKB1 P19838 1/20 0.43
▸ PPARG P37231 1/20 0.43
▸ NFKB2 Q00653 1/20 0.43
▸ RELA Q04206 1/20 0.43
▸ NCOA2 Q15596 1/20 0.43
▸ NCOA1 Q15788 1/20 0.43
▸ NCOA3 Q9Y6Q9 1/20 0.43
▸ CYP2C9 P11712 2/20 0.42
▸ CYP2C19 P33261 2/20 0.42
▸ CYP2D6 P10635 1/20 0.42
▸ MAPT P10636 6/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ KDM4E B2RXH2 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6481622 1.00 PPARD (0.61) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6481626 1.00 PPARD (0.61) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6480886 0.94 PPARD (0.58) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6480875 0.94 PPARD (0.58) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6473765 0.89 PPARD (0.48) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6473974 0.89 PPARD (0.48) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6473774 0.89 PPARD (0.48) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6528571 0.88 PPARD (0.77) PPARDNPC1RAB9ASMN1; SMN2PPARG
SCHEMBL6474374 0.87 PPARD (0.50) PPARDNPC1RAB9AALDH1A1CYP1A2
SCHEMBL6474363 0.87 PPARD (0.50) PPARDNPC1RAB9AALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6869967-B2 Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives NOVO NORDISK A/S (DK) 2005-03-22 — — US claimed
EP-1414778-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. NOVO NORDISK A/S (DK) 2004-05-06 — — EP claimed
US-20030139473-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2003-07-24 — — US claimed
WO-2003011807-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. NOVO NORDISK A/S (DK) 2003-02-13 — — WO claimed
US-6869967-B2 Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives NOVO NORDISK A/S (DK) 2005-03-22 — — US disclosed
EP-1414778-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. NOVO NORDISK A/S (DK) 2004-05-06 — — EP disclosed
US-20030139473-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2003-07-24 — — US disclosed
WO-2003011807-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. NOVO NORDISK A/S (DK) 2003-02-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139473-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA PPARD 2/4885NPC1 546/4885RAB9A 2668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.