SCHEMBL6482973

SCHEMBL6482973

O=C(O)Cc1ccc(OCC=C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(I)c1

nearest known ligand 0.65

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 6/20 0.65
FFAR1 O14842 1/20 0.40
MRGPRX4 Q96LA9 2/20 0.39
TDP1 Q9NUW8 2/20 0.38
GAA P10253 3/20 0.37
TSHR P16473 2/20 0.37
ALDH1A1 P00352 1/20 0.37
NFKB1 P19838 1/20 0.37
CA2 P00918 1/20 0.37
PTGDR2 Q9Y5Y4 3/20 0.36
PTGDR Q13258 2/20 0.36
NR4A2 P43354 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6481912 0.90 PPARD (0.61) PPARDFFAR1TDP1GAATSHR
SCHEMBL6482415 0.88 FFAR1 (0.55) PPARDFFAR1MRGPRX4
SCHEMBL6482972 0.88 PPARD (0.58) PPARDFFAR1TDP1GAATSHR
SCHEMBL6474350 0.88 PPARD (0.82) PPARDMRGPRX4TDP1TSHRCA2
SCHEMBL6528160 0.87 PPARD (0.57) PPARDFFAR1GAATSHRALDH1A1
SCHEMBL6473160 0.86 PPARD (0.71) PPARDMRGPRX4GAATSHR
SCHEMBL6474893 0.85 PPARD (0.55) PPARDFFAR1TDP1GAATSHR
SCHEMBL6474472 0.83 PPARD (0.79) PPARDMRGPRX4TDP1GAATSHR
SCHEMBL6474172 0.82 PPARD (0.52) PPARDFFAR1
SCHEMBL6474911 0.82 PPARD (0.52) PPARDFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6869967-B2 Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives NOVO NORDISK A/S (DK) 2005-03-22 US claimed
US-20030139473-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2003-07-24 US claimed
US-6869967-B2 Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives NOVO NORDISK A/S (DK) 2005-03-22 US disclosed
US-20030139473-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2003-07-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139473-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA PPARD 2/4885FFAR1 22/4885MRGPRX4 821/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.