Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.50 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.50 |
| ▸ | PDE2A | O00408 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6484254 | 0.93 | PDE3B (0.50) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6475324 | 0.92 | PDE3B (0.47) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6487561 | 0.91 | DYRK1A (0.49) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6480290 | 0.90 | MC4R (0.51) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6476018 | 0.89 | PDE3B (0.48) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6485221 | 0.88 | MC4R (0.58) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6474142 | 0.88 | MC4R (0.52) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6484684 | 0.88 | DRD3 (0.56) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6482865 | 0.88 | PDE3B (0.48) | PDE3BPDE3AP2RY12PDE2ADYRK1A | |
| SCHEMBL6474588 | 0.88 | MC4R (0.59) | PDE3BPDE3AP2RY12PDE2AMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855714-B2 | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-02-15 | — | — | US | claimed |
| EP-1404321-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | Schering Aktiengesellschaft (DE) | 2004-04-07 | — | — | EP | claimed |
| WO-2003004023-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-16 | — | — | WO | claimed |