Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | UBE2M | P61081 | 3/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912843 | 0.90 | C5AR1 (0.57) | C5AR1SMN1; SMN2LMNAL3MBTL1KCNH2 | |
| SCHEMBL649595 | 0.87 | C5AR1 (0.52) | C5AR1SMN1; SMN2LMNAL3MBTL1KCNH2 | |
| SCHEMBL1912842 | 0.86 | C5AR1 (0.62) | C5AR1SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL648841 | 0.85 | C5AR1 (0.65) | C5AR1SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL650118 | 0.84 | C5AR1 (0.63) | C5AR1SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL1912838 | 0.84 | C5AR1 (0.57) | C5AR1SMN1; SMN2LMNAL3MBTL1KCNH2 | |
| SCHEMBL649792 | 0.83 | C5AR1 (0.62) | C5AR1SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL647749 | 0.83 | C5AR1 (0.73) | C5AR1SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL650680 | 0.80 | C5AR1 (0.64) | C5AR1SMN1; SMN2LMNAL3MBTL1TDP1 | |
| SCHEMBL648190 | 0.80 | C5AR1 (0.65) | C5AR1SMN1; SMN2LMNAL3MBTL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |