Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | VHL | P40337 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500806 | 0.86 | PTGER4 (0.42) | SMN1; SMN2PTGER4PTGER2ROCK2 | |
| SCHEMBL6484313 | 0.81 | SRD5A2 (0.38) | SMN1; SMN2P2RX7EGLN1 | |
| SCHEMBL6475669 | 0.80 | EPHX2 (0.42) | SMN1; SMN2CNR2VHLP2RX7 | |
| SCHEMBL6475411 | 0.79 | AR (0.37) | SMN1; SMN2ROCK2P2RX7MAPK8 | |
| SCHEMBL6483444 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2P2RX7 | |
| SCHEMBL6482198 | 0.78 | HPGD (0.43) | SMN1; SMN2MAPK8AKR1B1 | |
| SCHEMBL6482506 | 0.76 | HAO1 (0.44) | SMN1; SMN2PTGER4PTGER2 | |
| SCHEMBL6474340 | 0.75 | AR (0.39) | SMN1; SMN2PTGER4PTGER2EGLN1 | |
| SCHEMBL6476121 | 0.74 | PDE4A (0.44) | SMN1; SMN2PTGER4PTGER2 | |
| SCHEMBL5608707 | 0.73 | MAPK8 (0.52) | PTGER4PTGER2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869945-B2 | Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC (US) | 2005-03-22 | — | — | US | disclosed |