Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | YES1 | P07947 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | HCK | P08631 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18070204 | 0.86 | LCK (0.69) | LCKMAPK14RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL775200 | 0.83 | LCK (0.65) | LCKMAPK14MAPK13ABL1EGFR | |
| SCHEMBL773380 | 0.83 | LCK (0.78) | LCKMAPK14RAB9ANPC1MAPK13 | |
| SCHEMBL773130 | 0.81 | LCK (0.62) | LCKMAPK14RAB9ASMN1; SMN2MAPK13 | |
| SCHEMBL775254 | 0.80 | LCK (0.72) | LCKMAPK14MAPK13ABL1EGFR | |
| SCHEMBL772868 | 0.80 | LCK (1.00) | LCKMAPK14MAPK13ABL1EGFR | |
| SCHEMBL22038674 | 0.79 | LCK (0.69) | LCKMAPK14MAPK13ABL1EGFR | |
| SCHEMBL774817 | 0.79 | LCK (0.60) | LCKMAPK14RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL772252 | 0.79 | LCK (0.76) | LCKMAPK14MAPK13ABL1EGFR | |
| SCHEMBL1540058 | 0.79 | LCK (0.74) | LCKMAPK14MAPK13EGFRFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6979694-B2 | Drugs such as (5-(((2,4,6-Trimethylphenyl)amino)carbonyl)-4-methyl-2-thiazolyl)carbamic acid, 1,1-dimethylethyl ester, used as enzyme inhibitors, for prohylaxis of inflammatory bowel disease; modulation of immunology | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-27 | — | — | US | disclosed |