Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6492518 | 1.00 | DRD3 (0.46) | DRD3THRBHRH2HRH1PLA2G2A | |
| SCHEMBL6485781 | 0.82 | KDM4E (0.53) | HRH2HRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6500035 | 0.82 | KDM4E (0.53) | HRH2HRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6485461 | 0.82 | KDM4E (0.53) | HRH2HRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6500436 | 0.82 | KDM4E (0.53) | HRH2HRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6486426 | 0.81 | KDM4E (0.53) | HRH2HRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6495420 | 0.79 | DRD3 (0.38) | DRD3HRH2HRH1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6494983 | 0.79 | DRD3 (0.38) | DRD3HRH2HRH1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6484973 | 0.79 | DRD3 (0.38) | DRD3HRH2HRH1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6500305 | 0.79 | KDM4E (0.53) | HRH2HRH1KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861432-B2 | Piperazine derivatives that destabilize androgen receptors | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-03-01 | — | — | US | disclosed |