Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557133 | 0.89 | GRM2 (0.79) | GRM2CYP3A4RAB9ASMN1; SMN2 | |
| SCHEMBL5557800 | 0.88 | GRM2 (0.80) | GRM2CYP3A4GRM3RAB9ASMN1; SMN2 | |
| SCHEMBL5557734 | 0.86 | GRM2 (0.69) | GRM2CYP3A4RAB9ASMN1; SMN2 | |
| SCHEMBL5562802 | 0.86 | GRM2 (0.73) | GRM2CYP3A4GRM3 | |
| SCHEMBL5557631 | 0.84 | GRM2 (1.00) | GRM2CYP3A4RAB9ASMN1; SMN2 | |
| SCHEMBL5563530 | 0.84 | GRM2 (0.81) | GRM2CYP3A4GRM3 | |
| SCHEMBL6478021 | 0.83 | GRM2 (0.72) | GRM2CYP3A4GRM3RAB9ASMN1; SMN2 | |
| SCHEMBL5557486 | 0.83 | GRM2 (0.78) | GRM2CYP3A4RAB9ASMN1; SMN2 | |
| SCHEMBL5558442 | 0.83 | GRM2 (0.64) | GRM2CYP3A4RAB9ASMN1; SMN2 | |
| SCHEMBL17336850 | 0.83 | GRM2 (0.61) | GRM2CYP3A4GRM3RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949542-B2 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives | HOFFMAN-LA ROCHE INC. (US) | 2005-09-27 | — | — | US | disclosed |
| US-20030166639-A1 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166639-A1 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives | CYP1B1, GRIN2B, CYP4B1 | GRM2 140/4885CYP3A4 188/4885GRM3 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.