Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14572910 | 0.94 | C5AR1 (0.41) | C5AR1PTGESALOX5TAS2R14LTA4H | |
| SCHEMBL653426 | 0.92 | C5AR1 (0.38) | C5AR1ALDH1A1TSHRHPGDGAA | |
| SCHEMBL1913100 | 0.92 | C5AR1 (0.42) | C5AR1PTGESALOX5TAS2R14LTA4H | |
| SCHEMBL650523 | 0.90 | C5AR1 (0.50) | C5AR1PTGESALOX5TAS2R14LTA4H | |
| SCHEMBL651692 | 0.89 | C5AR1 (0.40) | C5AR1PTGESALOX5TAS2R14LTA4H | |
| SCHEMBL651302 | 0.88 | C5AR1 (0.46) | C5AR1PTGESALOX5TAS2R14LTA4H | |
| SCHEMBL652511 | 0.84 | C5AR1 (0.39) | C5AR1ALDH1A1PTGDR2MEN1KMT2A | |
| SCHEMBL651099 | 0.83 | C5AR1 (0.58) | C5AR1PTGESALOX5ALDH1A1TSHR | |
| SCHEMBL652538 | 0.83 | C5AR1 (0.39) | C5AR1ALDH1A1TSHRHPGDGAA | |
| SCHEMBL1913102 | 0.83 | C5AR1 (0.52) | C5AR1PTGESALOX5TAS2R14LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |