Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974680 | 0.76 | — | — | |
| SCHEMBL3972365 | 0.72 | KDM4E (0.34) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL3967439 | 0.71 | KDM4E (0.32) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL3973617 | 0.67 | KDM4E (0.31) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL3970831 | 0.67 | KDM4E (0.33) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL3968505 | 0.67 | KDM4E (0.32) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL3971845 | 0.67 | KDM4E (0.32) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL3962249 | 0.67 | KDM4E (0.32) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL10446780 | 0.66 | KDM4E (0.36) | KDM4EHCRTR1LMNAMAPT | |
| SCHEMBL3974069 | 0.64 | KDM4E (0.32) | KDM4EHCRTR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884806-B2 | Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-26 | — | — | US | disclosed |