Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 10/20 | 0.44 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974683 | 0.82 | POLB (0.53) | HSD17B10ALDH1A1HPGDKDM4EPARP1 | |
| SCHEMBL24995382 | 0.80 | HSD17B10 (0.49) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL4125230 | 0.80 | MGAM (0.50) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL28871223 | 0.79 | HSD17B10 (0.47) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL7966359 | 0.79 | MEN1 (0.50) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL4118985 | 0.79 | HSD17B10 (0.47) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL1272228 | 0.79 | PSMB8 (0.51) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL29967781 | 0.79 | HSD17B10 (0.47) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL3969023 | 0.78 | HSD17B10 (0.44) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL19540004 | 0.76 | HSD17B10 (0.45) | HSD17B10ALDH1A1HPGDKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884806-B2 | Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-26 | — | — | US | disclosed |