Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 9/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823117 | 0.79 | CSNK1D (0.57) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL5397818 | 0.76 | CSNK1D (0.54) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL5379446 | 0.75 | NTRK1 (0.46) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL5378106 | 0.75 | MAP2K4 (0.48) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL8254436 | 0.74 | CSNK1D (0.52) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL3756031 | 0.72 | MAP2K4 (0.67) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL5376642 | 0.72 | MAP2K4 (0.52) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK2 | |
| SCHEMBL5372837 | 0.72 | MAPK1 (0.45) | MAP2K4MAPK1MAPK6MAPKAPK3MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL27750633 | 0.71 | MAP2K4 (0.65) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 | |
| SCHEMBL5387317 | 0.71 | CSNK1D (0.59) | CSNK1DMAP2K4MAPK1MAPK6MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897231-B2 | Indazole derivatives as JNK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, INC. (US) | 2005-05-24 | — | — | US | disclosed |