Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 7/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.36 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.36 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381307 | 0.88 | CSNK1D (0.63) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL5387634 | 0.87 | CSNK1D (0.62) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL5372371 | 0.86 | CSNK1D (0.64) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL5383834 | 0.85 | CSNK1D (0.60) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL5373431 | 0.83 | CSNK1D (0.68) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL5381786 | 0.82 | CSNK1D (0.62) | CSNK1DNTRK1MPOMAP2K4MAPK1 | |
| SCHEMBL5383360 | 0.82 | CSNK1D (0.62) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL5372751 | 0.80 | CSNK1D (0.62) | CSNK1DNTRK1MAP2K4MAPK1MKNK1 | |
| SCHEMBL5372967 | 0.80 | CSNK1D (0.64) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 | |
| SCHEMBL5377874 | 0.80 | CSNK1D (0.67) | CSNK1DNTRK1MAP2K4MAPK1MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897231-B2 | Indazole derivatives as JNK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, INC. (US) | 2005-05-24 | — | — | US | disclosed |