Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 7/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12971485 | 0.94 | PTPN1 (0.54) | PTPN1PTPN2BRD4MRGPRX1 | |
| SCHEMBL648987 | 0.92 | PTPN1 (0.53) | PTPN1PTPN2TP53GAAMAPT | |
| SCHEMBL648664 | 0.91 | PTPN1 (0.55) | PTPN1PTPN2PTGES2TP53GAA | |
| SCHEMBL645929 | 0.90 | PTPN1 (0.58) | PTPN1PTPN2TP53GAAMAPT | |
| SCHEMBL648320 | 0.89 | PTPN1 (0.57) | PTPN1PTPN2 | |
| SCHEMBL646568 | 0.89 | PTPN1 (0.52) | PTPN1PTPN2GAAMAPTHSD17B10 | |
| SCHEMBL12971497 | 0.86 | PTPN1 (0.55) | PTPN1PTPN2 | |
| SCHEMBL648527 | 0.84 | PTPN1 (0.56) | PTPN1PTPN2BRD4MRGPRX1 | |
| SCHEMBL647690 | 0.84 | PTPN1 (0.58) | PTPN1PTPN2TP53MAPTBRD4 | |
| SCHEMBL12971426 | 0.84 | PTPN1 (0.53) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963294-B1 | 1,2,5-THIAZOLIDINE DERIVATIVES USEFUL FOR TREATING CONDITIONS MEDIATED BY PROTEIN TYROSINE PHOSPHATASES (PTPASE) | NOVARTIS AG (CH) | 2012-10-10 | — | — | EP | claimed |
| US-8119666-B2 | 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase) | NOVARTIS AG (CH) | 2012-02-21 | — | — | US | claimed |
| US-8119666-B2 | 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase) | NOVARTIS AG (CH) | 2012-02-21 | — | — | US | disclosed |