Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254004 | 1.00 | KDR (0.60) | KDRCSF1RMEN1KMT2AKCNK3 | |
| SCHEMBL5249872 | 0.87 | KDR (0.56) | KDRKMT2AKCNK3POLBKCNK9 | |
| SCHEMBL5246823 | 0.83 | KDR (0.44) | KDRMEN1KMT2ALMNAMAPT | |
| SCHEMBL5255512 | 0.83 | KCNK3 (0.51) | KDRMEN1KMT2AKCNK3KCNK9 | |
| SCHEMBL5247789 | 0.83 | KDR (0.55) | KDRMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5247750 | 0.82 | KDR (0.59) | KDRKCNK3POLBKCNK9SNCA | |
| SCHEMBL5251706 | 0.82 | KDR (0.45) | KDRMEN1KMT2AKCNK3POLB | |
| SCHEMBL5248278 | 0.80 | KDR (0.59) | KDRMEN1KMT2AKCNK3KCNK9 | |
| SCHEMBL5249333 | 0.79 | KDR (0.58) | KDRMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL5250961 | 0.79 | KMT2A (0.43) | KDRMEN1KMT2AKCNK3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884890-B2 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-04-26 | — | — | US | disclosed |