Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.41 |
| ▸ | TP53 | P04637 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283758 | 0.91 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL5251150 | 0.88 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL5248181 | 0.85 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL6493718 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL6283765 | 0.80 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL6278366 | 0.80 | CDK4 (0.35) | — | |
| SCHEMBL5249126 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL5253124 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL5247212 | 0.78 | MAPT (0.36) | KDM4EALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL5522745 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884890-B2 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-04-26 | — | — | US | disclosed |