Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6493844 | 1.00 | EGFR (0.54) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL6495498 | 0.93 | EGFR (0.58) | EGFRERBB2ERBB4 | |
| SCHEMBL6495493 | 0.93 | EGFR (0.58) | EGFRERBB2ERBB4 | |
| SCHEMBL6500373 | 0.89 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL1418433 | 0.89 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL1418184 | 0.87 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL1418187 | 0.87 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL1417995 | 0.83 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL6493830 | 0.83 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL6505169 | 0.83 | EGFR (0.66) | EGFRERBB2ERBB4ERBB3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |