Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 9/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841808 | 0.93 | MAPK14 (0.54) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4840232 | 0.89 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4834276 | 0.89 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL6503638 | 0.89 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL6495727 | 0.88 | MAPK14 (0.43) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL6495478 | 0.88 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14110009 | 0.87 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL13936120 | 0.85 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14109709 | 0.84 | MAPK14 (0.57) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4840075 | 0.84 | MAPK14 (0.57) | MAPK14MAPK11MAPK13MAPK12NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288299-A1 | Azaindole derivatives as inhibitors of p38 kinase | SCIOS INC. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288299-A1 | Azaindole derivatives as inhibitors of p38 kinase | MAPKAPK2, MAPK1, MAPK3 | MAPK14 21/4885MAPK11 44/4885MAPK13 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.