Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | UBE2M | P61081 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134641 | 0.94 | C5AR1 (0.45) | C5AR1UBE2MDCUN1D1CRHR1TSHR | |
| SCHEMBL5136054 | 0.93 | C5AR1 (0.42) | C5AR1UBE2MDCUN1D1TSHRCXCR3 | |
| SCHEMBL650670 | 0.93 | C5AR1 (0.46) | C5AR1UBE2MDCUN1D1CRHR1TSHR | |
| SCHEMBL5134962 | 0.91 | C5AR1 (0.48) | C5AR1CRHR1TSHRHSD11B1NR1H3 | |
| SCHEMBL1912954 | 0.90 | C5AR1 (0.45) | C5AR1UBE2MDCUN1D1CRHR1TSHR | |
| SCHEMBL5135207 | 0.90 | C5AR1 (0.42) | C5AR1UBE2MDCUN1D1CRHR1TSHR | |
| SCHEMBL652185 | 0.89 | C5AR1 (0.63) | C5AR1UBE2MDCUN1D1TSHRKDM4E | |
| SCHEMBL648503 | 0.88 | C5AR1 (0.47) | C5AR1UBE2MDCUN1D1CRHR1TSHR | |
| SCHEMBL648089 | 0.88 | C5AR1 (0.47) | C5AR1CRHR1TSHRHSD11B1NR1H3 | |
| SCHEMBL5135213 | 0.87 | C5AR1 (0.42) | C5AR1UBE2MDCUN1D1CRHR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |