Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 7/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496113 | 0.98 | EGFR (0.70) | EGFRERBB2KDR | |
| SCHEMBL1418433 | 0.85 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL6500373 | 0.85 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL1417945 | 0.85 | EGFR (0.83) | EGFRERBB2KDR | |
| SCHEMBL1418247 | 0.85 | EGFR (0.83) | EGFRERBB2KDR | |
| SCHEMBL4231542 | 0.84 | KDR (0.60) | EGFRERBB2KDR | |
| SCHEMBL4226680 | 0.84 | KDR (0.60) | EGFRERBB2KDR | |
| SCHEMBL1419134 | 0.83 | EGFR (0.83) | EGFRERBB2KDR | |
| SCHEMBL1417881 | 0.83 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL1417882 | 0.83 | EGFR (0.62) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |