Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL758123 | 0.81 | KDM4E (1.00) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL1095815 | 0.81 | KDM4E (0.68) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL31555016 | 0.81 | KDM4E (0.68) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL31418070 | 0.81 | KDM4E (1.00) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL23263005 | 0.78 | KDM4E (0.64) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL3824227 | 0.78 | KDM4E (0.69) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL22329023 | 0.78 | KDM4E (0.64) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL22569116 | 0.77 | HTT (0.78) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL19688299 | 0.77 | POLB (0.72) | KDM4EPOLBHCAR2HTTALDH1A1 | |
| SCHEMBL8124981 | 0.77 | KDM4E (0.67) | KDM4EPOLBHCAR2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |