Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | FLT4 | P35916 | 3/20 | 0.50 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.50 |
| ▸ | ILK | Q13418 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 9/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HLA-A | P04439 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602572 | 0.87 | KDR (0.56) | KDRPDGFRBKITFLT4MAP3K20 | |
| SCHEMBL6505180 | 0.86 | KDR (0.63) | KDRPDGFRBKITFLT4MAP3K20 | |
| Hydrochloric Acid SCHEMBL6505932 | 0.85 | KDR (0.62) | KDRPDGFRBKITFLT4MAP3K20 | |
| SCHEMBL6482138 | 0.85 | KDR (0.60) | KDRPDGFRBKITFLT4MAP3K20 | |
| Hydrochloric Acid SCHEMBL6479719 | 0.84 | KDR (0.59) | KDRPDGFRBKITFLT4MAP3K20 | |
| SCHEMBL6497078 | 0.81 | KDR (0.58) | KDRPDGFRBKITFLT4MAP3K20 | |
| SCHEMBL6600180 | 0.80 | KDR (0.52) | KDRPDGFRBKITFLT4MAP3K20 | |
| Hydrochloric Acid SCHEMBL6600046 | 0.80 | KDR (0.51) | KDRPDGFRBKITFLT4MAP3K20 | |
| SCHEMBL6474476 | 0.80 | KDR (0.76) | KDRPDGFRBKITFLT4MAP3K20 | |
| SCHEMBL6494487 | 0.78 | KDR (0.66) | KDRPDGFRBKITFLT4MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903101-B1 | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | claimed |
| EP-1208096-B1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER AG (US) | 2004-04-28 | — | — | EP | claimed |
| US-6903101-B1 | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| EP-1208096-B1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER AG (US) | 2004-04-28 | — | — | EP | disclosed |