Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 15/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | VHL | P40337 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652182 | 0.92 | C5AR1 (0.41) | NR1H2NR1H3C5AR1CRHR1RXRA | |
| SCHEMBL5135263 | 0.92 | C5AR1 (0.42) | C5AR1CRHR1TSHRALDH1A1 | |
| SCHEMBL650029 | 0.90 | C5AR1 (0.40) | NR1H2NR1H3C5AR1CRHR1TSHR | |
| SCHEMBL5134968 | 0.89 | C5AR1 (0.42) | NR1H3C5AR1CRHR1TSHRALDH1A1 | |
| SCHEMBL5136285 | 0.88 | C5AR1 (0.42) | NR1H3C5AR1CRHR1TSHRALDH1A1 | |
| SCHEMBL5069970 | 0.88 | SLC6A2 (0.41) | C5AR1CRHR1TSHRALDH1A1 | |
| SCHEMBL649925 | 0.87 | CCR4 (0.44) | NR1H2NR1H3C5AR1CRHR1 | |
| SCHEMBL5134961 | 0.86 | C5AR1 (0.43) | NR1H3C5AR1CRHR1TSHRALDH1A1 | |
| SCHEMBL5137844 | 0.85 | C5AR1 (0.40) | C5AR1CRHR1TSHRALDH1A1 | |
| SCHEMBL5136687 | 0.85 | C5AR1 (0.43) | NR1H3C5AR1CRHR1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |