Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 14/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651214 | 0.92 | C5AR1 (0.50) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL1913082 | 0.92 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL651163 | 0.91 | C5AR1 (0.49) | C5AR1TLR7PTGDR2CYP2C8CYP2C9 | |
| SCHEMBL651030 | 0.90 | C5AR1 (0.47) | C5AR1TLR7PTGDR2CYP2C8CYP2C9 | |
| SCHEMBL649777 | 0.89 | C5AR1 (0.55) | C5AR1SIRT2 | |
| SCHEMBL1913101 | 0.89 | C5AR1 (0.42) | C5AR1PTGDR2 | |
| SCHEMBL651713 | 0.89 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL651035 | 0.88 | C5AR1 (0.54) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL652376 | 0.88 | C5AR1 (0.58) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL650149 | 0.88 | C5AR1 (0.49) | C5AR1TLR7PTGDR2CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |