Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | GPR183 | P32249 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497923 | 1.00 | CAPN1 (0.48) | CAPN1NPC1RAB9ASMN1; SMN2GPR183 | |
| SCHEMBL6499373 | 0.90 | CAPN1 (0.48) | CAPN1NPC1RAB9ASMN1; SMN2GPR183 | |
| SCHEMBL6499376 | 0.90 | CAPN1 (0.48) | CAPN1NPC1RAB9ASMN1; SMN2GPR183 | |
| SCHEMBL6495756 | 0.87 | CAPN1 (0.47) | CAPN1NPC1RAB9ASMN1; SMN2GPR183 | |
| SCHEMBL6495765 | 0.87 | CAPN1 (0.47) | CAPN1NPC1RAB9ASMN1; SMN2GPR183 | |
| SCHEMBL6500056 | 0.84 | CAPN1 (0.50) | CAPN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6500054 | 0.84 | CAPN1 (0.50) | CAPN1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6497650 | 0.83 | NPC1 (0.60) | CAPN1NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL6498081 | 0.82 | CAPN1 (0.43) | CAPN1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL6498087 | 0.82 | CAPN1 (0.43) | CAPN1NPC1RAB9ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |