Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 9/20 | 0.49 |
| ▸ | ITGB2 | P05107 | 7/20 | 0.49 |
| ▸ | ICAM1 | P05362 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497963 | 1.00 | ITGAL (0.49) | ITGALITGB2ICAM1KDM4EALDH1A1 | |
| SCHEMBL6497948 | 1.00 | ITGAL (0.49) | ITGALITGB2ICAM1KDM4EALDH1A1 | |
| SCHEMBL6509099 | 0.93 | ITGAL (0.49) | ITGALITGB2ICAM1KDM4EALDH1A1 | |
| SCHEMBL6509091 | 0.93 | ITGAL (0.49) | ITGALITGB2ICAM1KDM4EALDH1A1 | |
| SCHEMBL6509111 | 0.93 | ITGAL (0.49) | ITGALITGB2ICAM1KDM4EALDH1A1 | |
| SCHEMBL6498029 | 0.91 | ITGAL (0.47) | ITGALITGB2ICAM1ALDH1A1NPC1 | |
| SCHEMBL6498043 | 0.91 | ITGAL (0.47) | ITGALITGB2ICAM1ALDH1A1NPC1 | |
| SCHEMBL6498020 | 0.91 | ITGAL (0.47) | ITGALITGB2ICAM1ALDH1A1NPC1 | |
| SCHEMBL6497168 | 0.89 | ITGAL (0.48) | ITGALITGB2ICAM1ALDH1A1NPC1 | |
| SCHEMBL6497150 | 0.89 | ITGAL (0.48) | ITGALITGB2ICAM1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |