Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.41 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651471 | 1.00 | GRK6 (0.45) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL650949 | 0.92 | GRK6 (0.48) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL650948 | 0.92 | GRK6 (0.48) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL650934 | 0.87 | MAPT (0.56) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL650933 | 0.87 | MAPT (0.56) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL651180 | 0.87 | MEN1 (0.43) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL651181 | 0.87 | MEN1 (0.43) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL649588 | 0.86 | MAPT (0.46) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL649589 | 0.86 | MAPT (0.46) | GRK6MAPTNPSR1RNASELMEN1 | |
| SCHEMBL652061 | 0.85 | MAPT (0.56) | GRK6MAPTNPSR1RNASELMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119812-B2 | Thiazolidinone derivative | SBI BIOTECH CO., LTD. (JP) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-20110190299-A1 | THIAZOLIDINONE DERIVATIVE | SBI BIOTECH CO., LTD. (JP) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190299-A1 | THIAZOLIDINONE DERIVATIVE | CDC7, CDK17, CDCA2 | GRK6 1322/4885MAPT 3657/4885NPSR1 4464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.