SCHEMBL6499556

SCHEMBL6499556

CCCn1cc(C(=O)O)c(Nc2ccc(I)cc2F)cc1=O.CCCn1cc(C(N)=O)c(Nc2ccc(I)cc2F)cc1=O

nearest known ligand 0.92

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 20/20 0.92
MAP2K2 P36507 19/20 0.92

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5623139 0.96 MAP2K2 (1.00) MAP2K1MAP2K2
SCHEMBL5623396 0.95 MAP2K1 (0.82) MAP2K1MAP2K2
SCHEMBL6530042 0.87 MAP2K1 (0.74) MAP2K1MAP2K2
SCHEMBL5623022 0.87 MAP2K2 (1.00) MAP2K1MAP2K2
SCHEMBL5622976 0.86 MAP2K1 (1.00) MAP2K1MAP2K2
SCHEMBL5622710 0.86 MAP2K1 (0.81) MAP2K1MAP2K2
SCHEMBL6533927 0.86 MAP2K1 (0.93) MAP2K1MAP2K2
SCHEMBL6529027 0.85 MAP2K1 (0.92) MAP2K1MAP2K2
SCHEMBL5623095 0.85 MAP2K1 (0.88) MAP2K1MAP2K2
SCHEMBL5622783 0.84 MAP2K2 (0.78) MAP2K1MAP2K2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005000818-A1 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2005-01-06 WO disclosed