SCHEMBL6500203

SCHEMBL6500203

[CH2]NC(=O)c1ccc(OC)c(OC)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.63
CYP3A4 P08684 1/20 0.63
CYP2C9 P11712 1/20 0.63
TSHR P16473 1/20 0.63
CYP2C19 P33261 1/20 0.63
CA12 O43570 1/20 0.61
CA1 P00915 1/20 0.61
CA2 P00918 1/20 0.61
CA4 P22748 1/20 0.61
CA6 P23280 1/20 0.61
CA7 P43166 1/20 0.61
TPMT P51580 1/20 0.61
CA9 Q16790 1/20 0.61
CA14 Q9ULX7 1/20 0.61
MAPT P10636 3/20 0.59
MAPK1 P28482 2/20 0.59
ALOX15 P16050 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
KMT2A Q03164 4/20 0.58
ALDH1A1 P00352 4/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12682342 0.85 MAPT (0.71) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL4151619 0.83 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL1436474 0.83 SMPD1 (0.66) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL28961053 0.81 CYP1A2 (0.63) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL2446906 0.81 CYP1A2 (0.63) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL29412632 0.81 CYP1A2 (0.63) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
Hydrochloric Acid SCHEMBL9638760 0.81 SMPD1 (0.64) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL7959710 0.81 NR1H4 (0.62) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL29415167 0.80 MAPK1 (0.77) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL335681 0.80 MAPK1 (0.77) CYP1A2CYP3A4CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005016883-A2 ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF ICOS CORPORATION (US) 2005-02-24 WO claimed
WO-2005016883-A2 ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF ICOS CORPORATION (US) 2005-02-24 WO disclosed
US-6245779-B1 ANALGESICS; ANTIINFLAMMATORY AGENTS OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 2001-06-12 US disclosed
CN-1262685-A Naphthyridine derivatives OTSUKA PHARMA CO LTD (JP) 2000-08-09 CN disclosed
EP-0997463-A1 NAPHTHYRIDINE DERIVATIVES OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 2000-05-03 EP disclosed
US-4342875-A STABILIZERS FOR OLEFIN POLYMERS CINCINNATI-MILACRON, INC. (US) 1982-08-03 US disclosed