Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 3/20 | 0.42 |
| ▸ | CHKA | P35790 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839529 | 0.75 | MAPK1 (0.49) | LMNA | |
| SCHEMBL5584248 | 0.69 | CHKA (0.42) | TNKSCHKAAXLWDR5 | |
| SCHEMBL15638220 | 0.69 | CDK6 (0.45) | CHKAAXLWDR5 | |
| Hydrochloric Acid SCHEMBL5584380 | 0.68 | CHKA (0.41) | TNKSCHKAAXLWDR5 | |
| SCHEMBL10071720 | 0.68 | CHKA (0.56) | TNKSCHKAAXLLMNA | |
| SCHEMBL6838606 | 0.68 | MAPK1 (0.46) | ROCK2KCNH2 | |
| SCHEMBL1926217 | 0.67 | MEN1 (0.42) | TNKSCHKA | |
| SCHEMBL5584587 | 0.67 | CNR2 (0.44) | TNKSCHKAPARP1POLBAXL | |
| Hydrochloric Acid SCHEMBL1925086 | 0.66 | MEN1 (0.42) | TNKSCHKA | |
| Hydrochloric Acid SCHEMBL5585056 | 0.66 | CNR2 (0.44) | TNKSCHKAPARP1POLBAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861428-B2 | Water-soluble phenylpyridazine compounds and compositions containing the same | KOWA CO., LTD. (JP) | 2005-03-01 | — | — | US | claimed |