Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.72 |
| ▸ | PDE1A | P54750 | 7/20 | 0.71 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.71 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.63 |
| ▸ | PDE6C | P51160 | 3/20 | 0.62 |
| ▸ | PDE6A | P16499 | 2/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
| ▸ | PDE6D | O43924 | 1/20 | 0.62 |
| ▸ | PDE9A | O76083 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | PDE6G | P18545 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30199721 | 1.00 | PDE5A (0.74) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL17390157 | 0.91 | PDE5A (0.84) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL14126907 | 0.88 | PDE5A (0.79) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL18714933 | 0.87 | PDE5A (0.82) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL8344627 | 0.86 | PDE5A (0.70) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL29083398 | 0.86 | PDE5A (0.68) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL5902073 | 0.86 | PDE5A (0.75) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL8211166 | 0.86 | PDE5A (0.75) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL15996153 | 0.86 | PDE5A (0.75) | PDE5AHDAC1HDAC6HDAC2PDE1A | |
| SCHEMBL8344900 | 0.86 | PDE5A (0.70) | PDE5AHDAC1HDAC6HDAC2PDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878708-B2 | Imidazotriazinones and the use thereof | BAYER AKTIENGESELLSCHAFT (DE) | 2005-04-12 | — | — | US | disclosed |