Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 9/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038681 | 0.88 | LSS (0.66) | LSSTP53GAAALOX15DRD4 | |
| SCHEMBL5038817 | 0.85 | LSS (0.64) | LSSTP53GAASMN1; SMN2DRD4 | |
| SCHEMBL5040185 | 0.82 | LSS (0.57) | LSSSMN1; SMN2 | |
| SCHEMBL5039830 | 0.80 | LSS (0.63) | LSS | |
| SCHEMBL5038608 | 0.78 | LSS (0.82) | LSS | |
| SCHEMBL5038773 | 0.77 | LSS (0.66) | LSSDRD4DRD2DRD3 | |
| SCHEMBL5039981 | 0.77 | LSS (0.71) | LSS | |
| SCHEMBL5035480 | 0.77 | LSS (0.67) | LSS | |
| SCHEMBL5045528 | 0.77 | LSS (0.67) | LSS | |
| SCHEMBL5035327 | 0.76 | LSS (0.48) | LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951879-B2 | Substituted benzo(b)thiophenes or benzoisothiazoles which inhibit 2,3-oxidosqualene-lanosterol cyclase which is required for the biosynthesis of cholesterol, ergosterol and other sterols | HOFFMANN-LA ROCHE INC. (US) | 2005-10-04 | — | — | US | claimed |