Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 2/20 | 0.40 |
| ▸ | ATP4B | P51164 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038922 | 1.00 | LSS (0.47) | LSSKDM4EADORA2AADORA1ATP4A | |
| SCHEMBL5043313 | 0.97 | LSS (0.51) | LSSADORA2AADORA1ESR1 | |
| SCHEMBL5043537 | 0.95 | LSS (0.49) | LSSKDM4EADORA2AADORA1ATP4A | |
| SCHEMBL5040038 | 0.92 | LSS (0.53) | LSSKDM4EADORA2AADORA1ATP4A | |
| SCHEMBL5043605 | 0.91 | LSS (0.53) | LSSKDM4EADORA2AADORA1ATP4A | |
| SCHEMBL5045631 | 0.88 | LSS (0.57) | LSSADORA2AADORA1ESR1 | |
| SCHEMBL5043221 | 0.88 | LSS (0.56) | LSSMAPT | |
| SCHEMBL5038821 | 0.84 | LSS (0.60) | LSSKDM4E | |
| SCHEMBL5043156 | 0.84 | LSS (0.62) | LSSATP4AATP4B | |
| SCHEMBL5038070 | 0.84 | LSS (0.48) | LSSKDM4EATP4AATP4BXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951879-B2 | Substituted benzo(b)thiophenes or benzoisothiazoles which inhibit 2,3-oxidosqualene-lanosterol cyclase which is required for the biosynthesis of cholesterol, ergosterol and other sterols | HOFFMANN-LA ROCHE INC. (US) | 2005-10-04 | — | — | US | disclosed |