Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503145 | 1.00 | MAPT (0.50) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL6503152 | 1.00 | MAPT (0.50) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL9510890 | 0.80 | TSHR (0.47) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL4146557 | 0.80 | TSHR (0.47) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL11418791 | 0.79 | TSHR (0.63) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL1066358 | 0.78 | MAPT (0.47) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL1066360 | 0.78 | MAPT (0.47) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL1066356 | 0.78 | MAPT (0.47) | MAPTLMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL8297430 | 0.77 | TSHR (0.60) | TSHRALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL17169101 | 0.77 | KDM4E (0.49) | MAPTLMNAL3MBTL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |