Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4127123 | 0.92 | KDM4E (0.38) | KDM4EALDH1A1TRPV3ALOX5APFEN1 | |
| Hydrochloric Acid SCHEMBL4127118 | 0.91 | KDM4E (0.37) | KDM4EALDH1A1TRPV3ALOX5APFEN1 | |
| Hydrochloric Acid SCHEMBL4131714 | 0.87 | PTPN1 (0.41) | KDM4EALDH1A1PTPN2PTPN1 | |
| SCHEMBL4121055 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1HPGDKMT2AATM | |
| SCHEMBL4131302 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1ALOX5APFEN1MEN1 | |
| Hydrochloric Acid SCHEMBL4121051 | 0.79 | KDM4E (0.39) | KDM4EALDH1A1HPGDKMT2AATM | |
| Hydrochloric Acid SCHEMBL4131296 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1ALOX5APFEN1MEN1 | |
| SCHEMBL4126264 | 0.77 | KDM4E (0.39) | KDM4EALDH1A1ADORA2AMEN1HPGD | |
| Hydrochloric Acid SCHEMBL4126261 | 0.76 | KDM4E (0.39) | KDM4EALDH1A1ADORA2AMEN1HPGD | |
| SCHEMBL4118701 | 0.76 | KDM4E (0.36) | KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |