Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | MC3R | P41968 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505169 | 1.00 | EGFR (0.66) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL6505438 | 0.91 | EGFR (0.62) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL1418934 | 0.90 | EGFR (0.65) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL1418935 | 0.90 | EGFR (0.65) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL6495498 | 0.89 | EGFR (0.58) | EGFRERBB2ERBB4 | |
| SCHEMBL6495493 | 0.89 | EGFR (0.58) | EGFRERBB2ERBB4 | |
| SCHEMBL30115349 | 0.89 | EGFR (0.80) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL1417881 | 0.88 | EGFR (0.62) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL1417882 | 0.88 | EGFR (0.62) | EGFRERBB2ERBB4ERBB3JAK3 | |
| SCHEMBL1418079 | 0.88 | EGFR (0.59) | EGFRERBB2ERBB4ERBB3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |