Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SI | P14410 | 1/20 | 0.54 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK3 | P49761 | 1/20 | 0.51 |
| ▸ | MELK | Q14680 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507601 | 0.83 | PIM1 (0.55) | ESRRACYP3A4PIM1PDE4BPIM3 | |
| SCHEMBL6514075 | 0.83 | PIM1 (0.55) | ESRRACYP3A4PIM1PDE4BPIM3 | |
| SCHEMBL6512714 | 0.81 | PIM1 (0.53) | ESRRACYP3A4PIM1PDE4BPIM3 | |
| SCHEMBL6507355 | 0.81 | PIM1 (0.53) | ESRRACYP3A4PIM1PDE4BPIM3 | |
| SCHEMBL6507951 | 0.81 | PIM1 (0.52) | PIM1PIM3PIM2MEN1KMT2A | |
| SCHEMBL6532952 | 0.81 | PIM1 (0.52) | PIM1PIM3PIM2MEN1KMT2A | |
| SCHEMBL6509896 | 0.81 | PIM1 (0.51) | ESRRACYP3A4PIM1PDE4BPIM3 | |
| SCHEMBL6509891 | 0.81 | PIM1 (0.51) | ESRRACYP3A4PIM1PDE4BPIM3 | |
| SCHEMBL6507809 | 0.81 | PIM1 (0.53) | ESRRACYP3A4PIM1PDE4BPIM3 | |
| SCHEMBL6510852 | 0.81 | MGAM (0.50) | ESRRACYP3A4PIM1PDE4BPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058813-A2 | THIODIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND DIAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS ANTIDIABETIC AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2005-06-30 | — | — | WO | claimed |
| WO-2005058813-A2 | THIODIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND DIAZOLIDINEDIONE DERIVATIVES AND THEIR USE AS ANTIDIABETIC AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2005-06-30 | — | — | WO | disclosed |