Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 11/20 | 0.35 |
| ▸ | CNR2 | P34972 | 9/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510398 | 0.88 | CNR1 (0.36) | CNR1CNR2ADORA2AADORA2BADORA1 | |
| SCHEMBL4840849 | 0.84 | CNR1 (0.40) | NPC1POLBRAB9ACNR1CNR2 | |
| SCHEMBL25362329 | 0.77 | CNR1 (0.38) | CNR1CNR2ALDH1A1 | |
| SCHEMBL5375929 | 0.76 | MAPT (0.45) | KDM4EPOLBHTTRAB9ACNR1 | |
| SCHEMBL25362057 | 0.75 | CNR1 (0.34) | CNR1CNR2 | |
| SCHEMBL6509422 | 0.74 | CNR1 (0.39) | KDM4ENPC1POLBHTTRAB9A | |
| SCHEMBL4840644 | 0.72 | CNR1 (0.40) | KDM4ENPC1RAB9ACNR1CNR2 | |
| SCHEMBL14577345 | 0.71 | MEN1 (0.62) | KDM4ENPC1POLBHTTRAB9A | |
| SCHEMBL4832926 | 0.70 | CNR1 (0.45) | KDM4ENPC1POLBHTTRAB9A | |
| SCHEMBL8261401 | 0.70 | CNR1 (0.45) | KDM4ENPC1POLBHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | disclosed |