SCHEMBL6507018

SCHEMBL6507018

Cc1nc(-c2c(F)cccc2Cl)nn1-c1ccc(COc2ncc(C(F)(F)F)cc2Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.42
GAA P10253 2/20 0.40
ATM Q13315 1/20 0.40
HPGD P15428 1/20 0.40
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
ALDH1A1 P00352 4/20 0.39
NPSR1 Q6W5P4 2/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
NPY1R P25929 1/20 0.39
NPY2R P49146 1/20 0.39
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
RECQL P46063 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6506918 0.89 MAPK14 (0.33) MRGPRX4HPGDKMT2AALDH1A1SMN1; SMN2
SCHEMBL6505997 0.85 MRGPRX4 (0.48) MRGPRX4L3MBTL1GAAATMHPGD
SCHEMBL8942727 0.84 MRGPRX4 (0.47) MRGPRX4L3MBTL1GAAATMHPGD
SCHEMBL6497856 0.83 MRGPRX4 (0.47) MRGPRX4L3MBTL1GAAATMHPGD
SCHEMBL8301628 0.81 MRGPRX4 (0.48) MRGPRX4L3MBTL1GAAATMHPGD
SCHEMBL8942950 0.80 MRGPRX4 (0.48) MRGPRX4L3MBTL1GAAATMHPGD
SCHEMBL6499919 0.77 KMT2A (0.38) ATMMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL8304100 0.76 MRGPRX4 (0.42) MRGPRX4L3MBTL1GAAATMHPGD
SCHEMBL6501811 0.75 MRGPRX4 (0.44) MRGPRX4L3MBTL1GAAATMHPGD
SCHEMBL6498190 0.74 MRGPRX4 (0.44) MRGPRX4L3MBTL1GAAATMHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050009834-A1 Azole compounds, process for preparation of the same and use thereof SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2005-01-13 US claimed
EP-1386915-A1 AZOLE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF Sumitomo Chemical Takeda Agro Company, Limited (JP) 2004-02-04 EP claimed
US-20050009834-A1 Azole compounds, process for preparation of the same and use thereof SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) 2005-01-13 US disclosed
EP-1386915-A1 AZOLE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF Sumitomo Chemical Takeda Agro Company, Limited (JP) 2004-02-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050009834-A1 Azole compounds, process for preparation of the same and use thereof C1S, CYP4B1, CYP4X1 MRGPRX4 440/4885L3MBTL1 1027/4885GAA 3580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.