Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.58 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312063 | 0.83 | GSK3B (0.57) | GSK3BSERPINE1KDM4EMEN1KMT2A | |
| SCHEMBL6313673 | 0.82 | GSK3B (0.56) | GSK3BKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6522334 | 0.82 | GSK3B (0.56) | GSK3BSERPINE1KDM4EMEN1KMT2A | |
| SCHEMBL23510959 | 0.78 | GRIN2D (0.58) | GSK3BKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6519951 | 0.77 | GSK3B (0.58) | GSK3BSERPINE1KDM4EMEN1KMT2A | |
| SCHEMBL11383585 | 0.77 | CSF1R (0.69) | GSK3BALDH1A1 | |
| SCHEMBL11375916 | 0.76 | KDM4E (0.61) | GSK3BSERPINE1KDM4EMEN1KMT2A | |
| SCHEMBL11983212 | 0.76 | SERPINE1 (0.57) | GSK3BSERPINE1MEN1KMT2ATDP1 | |
| SCHEMBL6507316 | 0.76 | GRIN2D (0.50) | GSK3BSERPINE1KDM4EMEN1KMT2A | |
| SCHEMBL6521717 | 0.75 | GSK3B (0.49) | GSK3BSERPINE1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | GSK3B 824/4885SERPINE1 1022/4885POLB 3257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.