Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 9/20 | 0.85 |
| ▸ | CACNA1B | Q00975 | 9/20 | 0.85 |
| ▸ | CACNB1 | Q02641 | 9/20 | 0.85 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | FNTA | P49354 | 1/20 | 0.50 |
| ▸ | FNTB | P49356 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541405 | 0.92 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5541469 | 0.90 | CACNA2D1 (0.80) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5543965 | 0.86 | CACNA2D1 (0.77) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5544042 | 0.85 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL6498386 | 0.82 | CACNA2D1 (0.80) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5547482 | 0.82 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5544073 | 0.81 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL4283306 | 0.80 | CACNA2D1 (0.76) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5549190 | 0.79 | CACNA2D1 (0.73) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5547406 | 0.78 | CACNA2D1 (1.00) | CACNA2D1CACNA1BCACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | NEUROMED TECHNOLOGIES INC. | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227999-A1 | Diarylamine derivatives as calcium channel blockers | ORAI1, CACNA1D, CACNA1C | CACNA2D1 51/4885CACNA1B 4/4885CACNB1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.