Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 7/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PDE5A | O76074 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6512719 | 0.98 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2AMAPTKDM4EGAA | |
| SCHEMBL10702053 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2AKDM4EAOC3MAOB | |
| SCHEMBL5879528 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2AMAPTKDM4EGAA | |
| SCHEMBL11248470 | 0.83 | KMT2A (0.43) | SMN1; SMN2KMT2ACDK5CDK5R1AOC3 | |
| SCHEMBL8008758 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMAPTKDM4EGAA | |
| SCHEMBL8409815 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMAPTKDM4EGAA | |
| Hydrochloric Acid SCHEMBL10703604 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AKDM4EAOC3MAOB | |
| SCHEMBL3478405 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMAPTKDM4EGAA | |
| SCHEMBL9839087 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMAPTKDM4EGAA | |
| Hydrochloric Acid SCHEMBL11249604 | 0.82 | AOC3 (0.43) | SMN1; SMN2KMT2AAOC3MAOBPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998040368-A1 | SYNTHESIS OF THIAZOLE DERIVATIVES | ALBEMARLE CORPORATION (US) | 1998-09-17 | — | — | WO | claimed |
| US-5731442-A | Synthesis of thiazole derivatives | ALBEMARLE CORPORATION (US) | 1998-03-24 | — | — | US | claimed |
| US-4347370-A | HISTAMINE H-2 ANTAGONISTS, INHIBIT GASTRIC ACID SECRETION | IMPERIAL CHEMICAL INDUSTRIES LTD. (GB) | 1982-08-31 | — | — | US | claimed |
| CN-111825633-B | Method for synthesizing 2-guanidyl thiazole compounds by one-pot method | 西华大学 | 2023-11-17 | — | — | CN | disclosed |
| CN-219111359-U | Stirring device for preparing famotidine preparation | 江苏大同盟制药有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-112006999-A | Preparation method of famotidine preparation for injection | 江苏大同盟制药有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-111825633-A | Method for synthesizing 2-guanidino thiazole compound by one-pot method | 西华大学 | 2020-10-27 | — | — | CN | disclosed |
| WO-2005009986-A1 | ONE-POT PREPARATION OF S-(GUANIDINO-4-YL-METHYL)-ISOTHIOUREA DIHYDROCHORIDE | TALLURI VEERA VENKATA SATYANAR (IN) | 2005-02-03 | — | — | WO | disclosed |
| US-5856501-A | Synthesis of thiazole derivatives | ALBEMARLE CORPORATION (US) | 1999-01-05 | — | — | US | disclosed |
| WO-1998040368-A1 | SYNTHESIS OF THIAZOLE DERIVATIVES | ALBEMARLE CORPORATION (US) | 1998-09-17 | — | — | WO | disclosed |
| US-5731442-A | Synthesis of thiazole derivatives | ALBEMARLE CORPORATION (US) | 1998-03-24 | — | — | US | disclosed |
| US-4837316-A | ANTIULCER AGENTS | FUJIREBIO KABUSHIKI KAISHA (JP) | 1989-06-06 | — | — | US | disclosed |
| EP-0284536-A1 | A process for the preparation of 3-(2-guanidinothiazol-4-yl-methylthio)propionitrile | CENTRO MARGA PARA LA INVESTIGACION S.A. (ES) | 1988-09-28 | — | — | EP | disclosed |
| EP-0214823-A2 | Alkylamide derivatives with H2-receptor antagonistic and cytoprotective action | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. (JP) | 1987-03-18 | — | — | EP | disclosed |
| EP-0128736-B1 | NOVEL 2-GUANIDINOTHIAZOLINE COMPOUNDS, THEIR PREPARATION, AND THEIR USE AS INTERMEDIATES | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1987-02-25 | — | — | EP | disclosed |
| US-4609737-A | DIHALOACETONE AND AMIDINOTHIOUREA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1986-09-02 | — | — | US | disclosed |
| US-4562261-A | 2-Guanidinothiazoline compounds, and process for preparing them | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1985-12-31 | — | — | US | disclosed |
| EP-0128736-A1 | Novel 2-guanidinothiazoline compounds, their preparation, and their use as intermediates | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1984-12-19 | — | — | EP | disclosed |
| EP-0057227-A1 | IMINO-ALKYL AND AMINO-NITRILE CYANO-GUANIDINES | Société de Recherches et de Synthèses Organiques SA (CH) | 1982-08-11 | — | — | EP | disclosed |
| WO-1982000462-A1 | IMINO-ALKYL AND AMINO-NITRILE CYANO-GUANIDINES | RECH SYNTHESES ORGAN (CH) | 1982-02-18 | — | — | WO | disclosed |