Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471072 | 0.91 | PTGER1 (0.47) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL4376110 | 0.90 | MAPK14 (0.50) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL4382368 | 0.88 | MAPK14 (0.56) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL4379002 | 0.87 | MAPK14 (0.49) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL4383322 | 0.87 | MAPK14 (0.58) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL4384407 | 0.85 | MAPK14 (0.58) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL4383567 | 0.85 | MAPK14 (0.60) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL13602834 | 0.84 | MAPK14 (0.55) | MAPK14MAOBROCK2MAPK12MAPK11 | |
| SCHEMBL4378989 | 0.83 | MAPK14 (0.46) | MAPK14MAOB | |
| SCHEMBL4374045 | 0.81 | MAPK14 (0.57) | MAPK14MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | MAPK14 53/4885MAOB 560/4885ROCK2 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.