Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15233047 | 0.94 | LCK (0.43) | LCKRHEBATMKDM4EALDH1A1 | |
| SCHEMBL5561008 | 0.93 | LCK (0.36) | LEF1LCKBRD4MAPTACHE | |
| SCHEMBL6511063 | 0.90 | RHEB (0.41) | LEF1LCKRHEBATMNPC1 | |
| SCHEMBL14879050 | 0.86 | LCK (0.43) | LCKMAPTESR2 | |
| SCHEMBL5561204 | 0.84 | RHEB (0.41) | LEF1LCKRHEBATMNPC1 | |
| SCHEMBL15233333 | 0.83 | BRD4 (0.48) | LCKRHEBATMNPC1RAB9A | |
| SCHEMBL5561415 | 0.82 | LCK (0.39) | LCKNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL15233045 | 0.78 | KDM4E (0.47) | LCKRHEBATMNPC1RAB9A | |
| SCHEMBL3417370 | 0.77 | HDAC1 (0.39) | LEF1LCKKDM4EMAPTHRAS | |
| SCHEMBL5560010 | 0.77 | MAPT (0.39) | LEF1LCKNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524899-B2 | Oligopeptide containing fused 6-membered ring forming complexes with double stranded dna; complexes can be used for identification of specific dsDNA sequences, inhibiting gene transcription, therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific gene | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-09-03 | — | — | US | disclosed |
| US-20050026174-A1 | Alternative heterocycles for DNA recognition | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026174-A1 | Alternative heterocycles for DNA recognition | DDB1, PCNA, DNA2 | LEF1 445/4885LCK 3761/4885RHEB 2514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.